Cisplatin induced toxicity
WebJun 21, 2024 · Sodium Thiosulfate and Cisplatin-Induced Hearing Loss Cisplatin is an effective treatment for hepatoblastoma but often leads to lifelong irreversible hearing … WebApr 28, 2024 · Cisplatin-Induced Reproductive Toxicity and Oxidative Stress: Ameliorative Effect of Kinetin . Authors Rania Abdel-Latif 1 , Moustafa Fathy 2 , Hend Ali Anwar 2 , Muhammad Naseem 3 4 , Thomas Dandekar 4 , Eman M Othman 2 4 Affiliations 1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Minia, …
Cisplatin induced toxicity
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WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in … WebMay 8, 2024 · Cisplatin chemotherapy is used alone or in combination to treat a variety of cancers, including ovarian, testicular, lung, cervical, bladder, head and neck, and gastric cancers as well as lymphoma, melanoma, and more. Although it offers options for many cancer types, its use may result in nephrotoxicity, a dose-limiting side effect.
WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024 WebBackground and propose: Cisplatin is a cytotoxic drug that triggers several toxicities. However, nephrotoxicity and ototoxicity remain major clinical limitations. The aim of our …
WebFeb 11, 2024 · Cisplatin is used to treat a wide range of childhood cancers and cisplatin-induced hearing loss (CIHL) is a common and debilitating toxicity. We aimed to address persistent knowledge gaps in CIHL by establishing benchmarks for the prevalence of and risk factors for CIHL. Methods WebApr 1, 2024 · Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is currently available.
WebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against …
WebOxidative stress plays a pivotal role in cisplatin-induced renal damage and several dietary antioxidants have been reported to ameliorate this secondary effect. Relevant findings on the protective effects of these antioxidant agents in cisplatin-induced nephrotoxicity are summarized in this paper. flixbus germany contactWebAlthough it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with the endoplasmic reticulum and mitochondria. It also activates apoptotic pathways and inflicts cellular damage via oxidative stress and inflammation. One of its dose limiting toxicities is its effects on the kidney. flixbus geneve aeroportWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … flixbus glasgow to londonWebOf these reactions, cisplatin-induced nephrotoxicity (CIN), cisplatin-induced peripheral neuropathy (CIPN), and cisplatin-induced ototoxicity (CIO) are the three most common of several CITs recognised thus far. While the anti-cancer activity of cisplatin is well understood, the mechanisms driving its toxicities have only begun to be defined. great gifts for herWebOct 26, 2005 · Cisplatin-induced cytotoxicity was determined by reduction of 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) as described previously ( Chen and Cederbaum, 1998 ). Measurement of intracellular GSH. Reduced glutathione (GSH) was assayed using a modified method of Hissin and Hilf (1976). flixbus glasgow to aberdeenWebAs is also true of other antineoplastic drugs, CDDP-induced toxicity has been mentioned frequently in the literature, but few reports have explored differences between generic … flixbus glassdoorWebNov 26, 2024 · Cisplatin-Induced Toxicity . Cisplatin, cis- diamine-dichloro-platinum (CDDP) is one of the most used chemotherapy drugs because it is effective against different types of tumors. Cisplatin is an alkylating agent which is cell-cycle-phase nonspecific. It can bond to proteins, RNA and DNA, inhibiting DNA synthesis and cell cycle and it can also ... flix bus glasgow to london