WebA regulação da HIF-1α pela disponibilidade de oxigênio é tão eficaz, que dentro de apenas 2 minutos células em hipóxia (in vitro) começam a acumular esta proteína (JEWELL et … Web21 de jun. de 2024 · The HIF-1α domain responsible for the dimerization with HIF-1β is outlined. B HIF-1α (FL) and HIF-1α (Del) domain structure: The deleted sequence in HIF …
Targeting HIF-1 alpha transcriptional activity drives ... - Nature
Web11 de abr. de 2024 · HIF-1α directly bound to the promoter of TMEM237 to transactivate its expression. The overexpression of TMEM237 was frequently detected in HCC and associated with poor clinical outcomes in patients. TMEM237 facilitated the proliferation, migration, invasion, and EMT of HCC cells and promoted tumor growth and metastasis in … Web3 de ago. de 2024 · HIF-1α is the main regulator of hypoxia signaling and is widely expressed (20-22). HIF-1α is involved in the occurrence and development of various liver diseases, including alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), viral hepatitis, liver fibrosis, drug-induced liver injury and hepatocellular carcinoma (HCC) … stcd6
HIF-1α pathway: role, regulation and intervention for cancer therapy
Web13 de jan. de 2024 · HIF-1α stabilization is critical for myeloid cell-mediated inflammation and neutrophil survival in hypoxic tissue. 1,2 The stabilization of HIF-1α has been shown to mediate the pro-inflammatory effects of hypoxia; however, prolonged or exaggerated expression of HIF-1α is linked to pathological inflammatory conditions such as … Web13 de abr. de 2024 · Furthermore, chromatin immunoprecipitation (ChIP) analysis and luciferase reporter assays revealed that hypoxia-inducible factor 1α (HIF-1α) specifically … WebM1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which … stceceliaboston/fatherjohnuni