Multidrug resistance-associated protein 1
WebMultidrug resistance-associated protein 1 ( MRP1) is a protein that in humans is encoded by the ABCC1 gene. [5] [6] Function [ edit] The protein encoded by this gene is a member of the superfamily of ATP-binding … WebIn this respect, 9 of the ABCC members are termed "multidrug resistance proteins" (MRPs1-9) due to their ability to mediate cancer multidrug resistance (MDR) by …
Multidrug resistance-associated protein 1
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Webresistance [re-zis´tans] 1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance. 2. the natural ability of a normal … Web9 aug. 2024 · MDR is typically associated with transmembrane proteins mediating efflux of administered drugs, thereby keeping their intracellular concentration below the threshold required to kill cells. Although expression assays based on flow cytometry and immunostaining have shown that multidrug resistance-associated protein 1 (MRP1) is …
Web23 sept. 2008 · Confers resistance to anticancer agents such as methotrexate (PubMed:11106685). 13 publications. Catalytic activity ... Multidrug resistance-associated protein 4; Gene names. Name. ABCC4. Synonyms. MOATB, MRP4. Organism names. Organism. Homo sapiens (Human) Taxonomic identifier. 9606 NCBI. Web2 iun. 2024 · P-glycoprotein was the earliest discovered efflux pump, followed by the multidrug resistance proteins (MPRs) MRP1 and MRP2 and the breast cancer …
WebT umor cell lines can develop cross-resistance to cytotoxic pharmacological agents derived from natural products (Gottesman and Pastan 1993).Multidrug resistance (MDR) involves an increase in the amounts of 170-kD P-glycoproteins (Pgp) that are encoded by the MDR genes (Endicott and Ling 1989).Pgp is involved in the export of a variety of natural drugs …
Web10 aug. 2011 · MRP1 was first discovered in an anthracycline-resistant cell line HL60/Adr which was the first major ABC transporter other than P-gp. This protein was shown to …
Web10 iun. 2024 · Multidrug resistance protein 1 (MRP1) is an ABC exporter that extrudes a variety of chemotherapeutic agents and native substrates. Previously, the structures of … csgo new mapsWebMultidrug resistance protein 1 localization in lipid raft domains and prostasomes in prostate cancer cell lines Alba Gomà,1,* Roser Mir,1–3,* Fina Martínez-Soler,1,4 Avelina … eabha investmentsWeb7 nov. 2014 · The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is … csgo new patchWebFrom the structural point of view, only the bovine ortholog of the multidrug-resistance associated protein 1 (bMRP1) has been resolved. We here used ms-scaled molecular dynamics simulations to investigate the structure and dynamics of bMRP1 in pre- and post-hydrolysis functional states. The present work aims to examine the slight but likely ... cs go new ranksWebP-glycoprotein. P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B … csgo new operation whenWebThe multidrug resistance 1 (MDR1) gene, encoding the membrane-resident P-glycoprotein (P-gp) that belongs to a family of ATP-binding cassette (ABC) transporters, has been … eabha morrisonWeb5 ian. 2024 · NM_102777.3 → NP_174329.1 multidrug resistance-associated protein 1 [Arabidopsis thaliana] See identical proteins and their annotated locations for … eabha mcmahon height